Fellow (Post Doc) (Computational Toxicology & Pharmacokinetic Modeling)
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Manhattan, KS 66502
About this Role:
The Institute of Computational Comparative Medicine (ICCM) and Department of Anatomy and Physiology within College of Veterinary Medicine are seeking applicants for a Fellow (Post Doc) to work in the Computational Toxicology and Pharmacokinetic Modeling Laboratory of Dr. Zhoumeng Lin. The incumbent of this position will be responsible for designing and developing physiologically based pharmacokinetic (PBPK) models for chemicals or nanoparticles in animals and humans for food safety assessment or risk assessment. This individual will also apply machine learning and neural network modeling methods to study the association of nanoparticle physiological properties and tissue distribution. This individual will receive training in PBPK modeling, dose-response assessment, risk assessment, computational toxicology, machine learning and/or neural network modeling.
We Support Diversity and Inclusion:
Kansas State University embraces diversity, and promotes inclusion in every sector of the institution. The university actively seeks candidates whose commitments and contributions will advance the University’s commitment to the Principles of Community.
Duties / Responsibilities:
The incumbent of this position will be mainly responsible for the development and applications of physiologically based pharmacokinetic (PBPK) models. Specific responsibilities include:
To design and develop PBPK models for environmental chemicals (e.g., per- and polyfluoroalkyl substances [PFAS]) or nanoparticles in animals and humans
To design and develop PBPK models for drugs in food-producing animals
To convert the developed PBPK models to web-based interfaces
To apply the PBPK models to conduct risk assessment
To use machine learning and neural network modeling methods to study the association between nanoparticle physicochemical properties and tissue distribution
Other responsibilities include:
Present research findings in professional conferences, such as Society of Toxicology, American Conference on Pharmacometrics, and American Academy of Veterinary Pharmacology and Therapeutics
Write manuscripts toward publication in high quality peer-reviewed journals in the field of pharmacology and toxicology
Prepare documents for grant applications and progress reports
Collaborate with other lab members and help on other computational modeling projects that are active in the lab, including quantitative systems pharmacology modeling projects, population-based nonlinear mixed effects pharmacokinetic (popPK or NLME-PK) modeling projects, and probabilistic risk assessment projects.
Required Minimum Qualifications:
Ph.D. in pharmacometrics, pharmacology, toxicology, epidemiology, biostatistics, environmental health, bioinformatics, engineering, or a related field
Strong interest in computational pharmacology and toxicology modeling
Willing to learn new knowledge and computational modeling techniques
Good verbal and written English skills
Ph.D. in which dissertation research was related to pharmacometric, pharmacokinetic, systems pharmacology, biostatistical, or bioinformatic modeling
Experience doing physiologically based pharmacokinetic (PBPK) modeling, quantitative systems pharmacology (QSP) modeling, population pharmacokinetic (popPK) modeling, dose-response modeling, biostatistical analysis of epidemiology/toxicology data, metabolomics analysis, or other relevant quantitative pharmacology and biostatistical skills
Experience with one of the following software programs, including R language, MATLAB, Systems Biology Markup Language (SBML), Pharmacometrics Markup Language (PharmML), Berkeley Madonna, acslX, Phoenix, PK-Sim, MoBi, Simcyp, or GastroPlus
Ability to professionally interact with collaborating scientists involved in these projects
Special Instructions to Applicants:
Please submit cover letter, resume, and contact information for three professional references
Screening of Applications Begins:
Screening of applications begins immediately
Salary Range / Pay Rate:
$ 47,476 – $ 65,000 annual salary
Equal Employment Opportunity:
Kansas State University is an Equal Opportunity Employer of individuals with disabilities and protected veterans and actively seeks diversity among its employees.
Background Screening Statement:
In connection with your application for employment, Kansas State University will procure a Background Screen on you as part of the process of considering your candidacy as an employee.